isotope dilution mass spectrometry

Isotope Dilution Mass Spectroscopy - an overview ...

13.3.3.2 Isotope dilution mass spectrometry. Isotope dilution mass spectrometry (IDMS) is based on the fact that many elements have two or more stable isotopes whose proportion in nature is constant. A known amount of a stable isotope is added to a sample and the ratio between the isotopes can then be measured by MS.

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Isotope dilution mass spectrometry: definitive methods and ...

Isotope dilution mass spectrometry: definitive methods and reference materials in clinical chemistry Ann Ist Super Sanita. 1991;27(3):401-10. Authors M G Giovannini 1 , G Pieraccini, G Moneti. Affiliation 1 Dipartimento di Farmacologia, Università degli Studi, Firenze. PMID: 1809059 Abstract ...

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Isotope dilution mass spectrometry - ScienceDirect

Sep 02, 1992  International Journal of Mass Spectrometry and Ion Processes, 118/119 (1992) 575-592 575 Elsevier Soence Publishers B.V., Amsterdam Isotope dilution mass spectrometry* Klaus G. Heumann Instttut J~r Anorgamsche Chemw der Umversttat Regensburg, Umversttdtsstrasse 31, W-8400 Regensburg (Germany) (Recewed 26 August 1991) ABSTRACT In the past isotope dduUon mass spectrometry

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Isotope-dilution mass spectrometry for exact ...

Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides Nat Protoc . 2019 Jan;14(1):283-312. doi: 10.1038/s41596-018-0094-6.

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Isotope dilution mass spectrometry: definitive methods and ...

Isotope dilution mass spectrometry: definitive methods and reference materials in clinical chemistry Ann Ist Super Sanita. 1991;27(3):401-10. Authors M G Giovannini 1 , G Pieraccini, G Moneti. Affiliation 1 Dipartimento di Farmacologia, Università degli Studi, Firenze. PMID: 1809059 Abstract ...

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Isotope-dilution mass spectrometry for exact ...

Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides Nat Protoc . 2019 Jan;14(1):283-312. doi: 10.1038/s41596-018-0094-6.

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Isotope Dilution Mass Spectrometry and the National ...

Jun 15, 1993  Isotope dilution mass spectrometry and implementation of a common accuracy base for routine medical laboratory analysis: Practice and prospects. Journal of Mass Spectrometry

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SW-846 Test Method 6800: Elemental and Molecular Speciated ...

Apr 14, 2020  The following document details the method used for the determination of total metals and elements, also speciated isotope dilution mass spectrometry (SIDMS) for the determination of elemental and molecular species. EPA is committed to respecting intellectual property, regardless of its source, including "outside" intellectual property created without participation by EPA, according to but

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Isotope dilution--mass spectrometry of thyroxin proposed ...

Isotope dilution--mass spectrometry of thyroxin proposed as a reference method. Möller B, Falk O, Björkhem I. We describe a highly accurate and specific method based on isotope dilution--mass spectrometry for assay of thyroxin in serum. A fixed amount of 2H2-labeled thyroxin is added to a fixed amount of serum.

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Analysis of Caffeine by Isotopic Dilution Using Mass ...

the analogue mixed with it in the isotope dilution analysis protocol. GC-MS instrumentation in the “specific ion monitoring”, or “SIM” mode is employed in the analytical procedure. In this configuration, the mass spectrometer samples the effluent GC stream only for ions of specifically designated masses or small ranges of designated masses.

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Chapter 3 The measurement technique of isotope dilution ...

Isotope dilution mass spectrometry is a direct ratio method which has been identified by the Consultative Committee for Amount of Substance (CCQM) of the International Committee for Weights and Measures (CIPM) to have the potential to be a primary method [1]. Isotope dilution measurements can be made with inductively coupled

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STABLE ISOTOPE DILUTION ASSAY MASS SPECTROMETRY

This technique, called stable isotope dilution-mass spectrometry (SID-MS), has a long history starting from the dawn of mass spectrometers. Isotope dilution analysis of complex organic compounds was first described in 1940 by Rittenberg and Foster (1). It is still being used in an ever widening range of quantitative applications (e.g.

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Applications of isotope dilution‐mass spectrometry in ...

Suyoung Lee, Byungjoo Kim, Jeongkwon Kim, Development of isotope dilution-liquid chromatography tandem mass spectrometry for the accurate determination of fluoroquinolones in animal meat products: Optimization of chromatographic separation for eliminating matrix effects on isotope ratio measurements, Journal of Chromatography A, 10.1016/j ...

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Standard Addition, Internal Standardization and Isotope ...

Isotope Dilution Mass Spectrometry. As discussed in part 10, ICP-MS suffers form matrix related effects upon the nebulizer and the signal intensity (quenching).In addition, even slight deposition on the sampler cone will cause drifting. Due in part to drifting, analysts have chosen to use the calibration curve technique with internal standardization over the technique of standard additions.

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Isotope dilution mass spectrometry — A primary method of ...

Nov 24, 2010  This article describes the application of isotope dilution mass spectrometry (IDMS) to the field of reference material (RM) characterisation focusing on the approach, which is applied by the IDMS group at BAM. Emphasis is placed on IDMS measurements of highest analytical quality. Basic principles as well as the equation system are being recalled.

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Isotope dilution mass spectrometry as a calibration method ...

The applicability of the isotope dilution (ID) technique for trace element determinations in powdered solid samples by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is demonstrated.LA-ICP-IDMS combines the advantage of the isotope dilution technique as a definitive method with the powerful capability of LA-ICP-MS for a fast and direct multi-element analysis of solid ...

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Isotope-Dilution Liquid Chromatography–Tandem Mass ...

Feb 01, 2013  After 2 liquid/liquid extractions of serum with a combination of ethyl acetate and hexane, we quantified testosterone by isotope-dilution liquid chromatography–tandem mass spectrometry with electrospray ionization in the positive ion mode monitoring 289→97 m/z (testosterone) and 292→112 m/z (3 C 13 testosterone). We used calibrator bracketing and gravimetric measurements to give higher ...

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Isotope dilution mass spectrometry (IDMS) of the elements ...

Isotope dilution mass spectrometry (IDMS) of the elements. Klaus G. Heumann, Institut für Anorganische Chemie der Universität Regensburg, Universitätsstrasse 31, D-8400 Regensburg, Germany. Search for more papers by this author. Klaus G. Heumann,

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Guideline on Isotope Dilution Mass Spectrometry (Technical ...

May 19, 2017  Isotope dilution mass spectrometry is used to determine the concentration of an element of interest in a bulk sample. It is a destructive analysis technique that is applicable to a wide range of analytes and bulk sample types. With this method, a known amount of a rare isotope

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Isotope dilution mass spectrometry - Willkommen

Contents Chapter 1 Introduction to Isotope Dilution MassSpectrometry (IDMS) 1.1 TheIsotopic Nature ofthe Elements 1 1.1.1 Radioactive andStable Isotopes: DecaySeries 4 1.1.2 Historical Perspective: Early Mass Spectrometry Experiments 5 1.1.3 TheIsotopic Composition ofthe Elements 6 1.1.4 TheAtomicWeight ofthe Elements 8 1.2 Isotope Fractionation andIsotope Enrichment 8 1.2.1

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METHOD 6800 ELEMENTAL AND SPECIATED ISOTOPE

Jul 30, 1999  ELEMENTAL AND SPECIATED ISOTOPE DILUTION MASS SPECTROMETRY SW-846 is not intended to be an analytical training manual. Therefore, method procedures are written based on the assumption that they will be performed by analysts who are formally trained in at least the basic principles of chemical analysis and in the use of the subject technology.

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High-resolution isotope-dilution mass spectrometry using ...

High-resolution isotope-dilution mass spectrometry using metabolism of isotope-labeled compounds: Application to drug metabolites J. James Vrbanac1*, Allen Hilgers1, Tyson Dubnicka1, F. Barclay Shilliday1, David Humphries2 and Roger N. Hayes2 1Discovery Sciences, MPI Research, Mattawan, MI 49071, USA 2Laboratory Sciences, MPI Research, Mattawan, MI 49071, USA

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Isotope dilution mass spectrometry (IDMS) of the elements ...

Isotope dilution mass spectrometry (IDMS) of the elements. Klaus G. Heumann, Institut für Anorganische Chemie der Universität Regensburg, Universitätsstrasse 31, D-8400 Regensburg, Germany. Search for more papers by this author. Klaus G. Heumann,

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Applications of isotope dilution‐mass spectrometry in ...

Mass Spectrometry Reviews. Volume 11, Issue 4. Article. Applications of isotope dilution‐mass spectrometry in clinical chemistry, pharmacokinetics, and toxicology. André P. de Leenheer. Corresponding Author. Laboratoria voor Medische Biochemie en voor Klinische Analyse, University of Ghent, Harelbekestraat 72, B‐9000 Ghent, Belgium.

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An isotope dilution liquid chromatography-tandem mass ...

May 20, 2021  Isotope dilution mass spectrometry (IDMS) has the highest metrological qualities, and the measurement value can be directly traced to the SI unit. At present, this technique is recognized as the first-level reference measurement principle for RMP establishment on the standardization of laboratory medicine [9,10,11,12,13]. Standardization ...

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Standard Addition, Internal Standardization and Isotope ...

Isotope Dilution Mass Spectrometry. As discussed in part 10, ICP-MS suffers form matrix related effects upon the nebulizer and the signal intensity (quenching).In addition, even slight deposition on the sampler cone will cause drifting. Due in part to drifting, analysts have chosen to use the calibration curve technique with internal standardization over the technique of standard additions.

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Creatinine Standardization Recommendations NIDDK

Calibrate serum creatinine methods to be traceable to an isotope dilution mass spectrometry (IDMS) reference measurement procedure. Standardization of method calibration will reduce the interlaboratory bias in results and yield more accurate estimated GFR (eGFR) when using the IDMS-traceable MDRD Study equation, the CKD-EPI, or the IDMS ...

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Overcoming matrix effects in quantitative LC‐MS analysis ...

Jun 28, 2021  Samples were analysed by an ultra-performance liquid chromatography separation coupled to tandem mass spectrometry (LC-MS/MS) and electrospray ionization (ESI). Isotopic dilution was investigated as a way to allow compensation of signal

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Isotope-Dilution Liquid Chromatography–Tandem Mass ...

Feb 01, 2013  After 2 liquid/liquid extractions of serum with a combination of ethyl acetate and hexane, we quantified testosterone by isotope-dilution liquid chromatography–tandem mass spectrometry with electrospray ionization in the positive ion mode monitoring 289→97 m/z (testosterone) and 292→112 m/z (3 C 13 testosterone). We used calibrator bracketing and gravimetric measurements to give higher ...

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Characterization of Stable Isotope Caffeine as Reference ...

Isotope dilution mass spectrometry (IDMS) is a precise method to determine concentrations of a given analyte in pure materials or in any type of matrix. This technique is based on the direct proportionality of mass fraction ratio and signal intensity ratio of the natural isotope and an isotopically labeled form of

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Testosterone Measurement by Isotope-Dilution Liquid ...

Aug 01, 2005  Methods: We used stable-isotope dilution liquid chromatography–tandem mass spectrometry (ID/LC-MS/MS) to measure testosterone in plasma and serum. The sample volume was 50 μL in duplicate; preparation and analysis were carried out in a single tube, and a batch of 192 tubes was analyzed in 17.5 h.

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(PDF) Determination of Lithium in Human Serum by Isotope ...

The therapeutic dose of lithium (Li) compounds, which are widely used for the treatment of psychiatric and hematologic disorders, is close to its toxic level; therefore, drug monitoring protocols are mandatory. Herein, we propose a fast, simple, and

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